Sansert

Common Name: methysergide

How does Sansert work?

Methysergide belongs to the class of medications called ergot alkaloids. It is used to prevent migraine or cluster headaches and other types of throbbing headaches. Methysergide is recommended when these headaches occur once a week or more, as well as for headaches that are so severe or uncontrollable that preventive therapy is needed no matter what the frequency. Methysergide is not used to treat headaches once they have started. It is not known exactly how this medication works, but it is thought to affect chemicals (called neurotransmitters) in the brain. Your doctor may choose to use a medication for conditions other than the ones listed in these drug information articles. If you're unsure why you are taking this medication, contact your doctor.

How should I use Sansert?

The usual starting dose of methysergide is 2 mg at night, increased gradually to 2 mg three times daily with meals. The maximum recommended daily dose is 12 mg and the usual maintenance dose ranges between 4 mg to 8 mg daily. The length of treatment prescribed by your doctor will vary according to circumstances but a trial of at least three weeks is usually prescribed. This medication must not be used continuously for a period of longer than six months at a time. There must be a period of three to four weeks without taking the medication before another course of treatment with this medication is started. When stopping the medication, the doctor will likely suggest reducing the dose of the medication gradually to prevent "rebound" headaches. Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor. It is very important that this medication be used on a regular schedule as prescribed by the doctor. If you miss a dose of this medication, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and continue on with your regular schedule. Do not double-up on doses.

What form(s) does Sansert come in?

Tablet

What should I NOT take with Sansert?

Methysergide should not be used by: anyone with a known or suspected allergy to the medication or its ingredients pregnant women anyone with peripheral vascular disease (circulation problems) anyone with severe arteriosclerosis (hardening of the arteries) anyone with severe high blood pressure anyone with coronary artery disease anyone with valvular heart disease anyone with phlebitis or cellulitis of the lower limbs anyone with pulmonary disease anyone with collagen disease anyone with reduced liver or kidney function anyone with urinary tract diseases anyone in a cachectic or septic state

Are there any other precautions or warnings for Sansert?

Duration of treatment: This medication should not be taken continuously for longer than six months at a time without a "drug-free interval" of three to four weeks. It is usually wise to decrease the dose of the medication gradually over two to three weeks before stopping it completely in order to avoid a "rebound" headache. Occupational hazards: Methysergide may cause drowsiness, dizziness, and lightheadedness. Use caution while operating dangerous machinery or motor vehicles. Weight gain: Methysergide may cause weight gain. Pregnancy: Do not use this medication is if you are pregnant. If you become pregnant while taking this medication, contact your doctor. Breast-feeding: Methysergide passes into breast milk. Breast-feeding is not recommended while taking this medication as it may cause the nursing child to have diarrhea, vomiting, weak pulse, or unstable blood pressure. Children: This medication is not recommended for use by children.