Arthrotec

Common Name: diclofenac sodium - misoprostol

How does Arthrotec work?

Diclofenac - misoprostol is used for the treatment of symptoms of rheumatoid arthritis and osteoarthritis. Diclofenac belongs to the class of medications known as non-steroidal anti-inflammatories (NSAIDs). It reduces pain and inflammation. Misoprostol helps to protect the stomach from irritation and stomach ulcers that can be caused by diclofenac. Your doctor may choose to use this medication for conditions other than the ones listed here. If you're unsure why you are taking this medication, contact your doctor.

How should I use Arthrotec?

The recommended adult dose is diclofenac - misoprostol is 50 mg (referring to the diclofenac portion of the medication) taken two or three times a day with food or milk or 75 mg taken twice daily with food or milk. Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones given here, do not change the way that you are taking the medication without consulting your doctor. It is very important that this medication be taken on a regular schedule exactly as prescribed by your doctor. If you miss a dose of this medication, take it as soon as you remember it. If it is almost time for your next dose, skip the missed dose and carry on with your regular schedule. Do not double-up on doses.

What form(s) does Arthrotec come in?

Arthrotec® is available in strengths of 50 mg and 75 mg. Arthrotec 50: Each white-to-off-white, round tablet, engraved "SEARLE" over "1411" on one side, with four "A"s on the circumference of the other, contains an enteric-coated core of diclofenac 50 mg, surrounded by an outer mantle containing misoprostol 200 µg. Nonmedicinal ingredients: castor oil, cellulose, cellulose acetate phthalate, colloidal silicon dioxide, cornstarch, crospovidone, diethyl phthalate, hydroxypropyl methylcellulose, lactose, magnesium stearate, povidone, and talc. Arthrotec 75: Each white-to-off-white, round tablet, engraved "SEARLE" over "1421" on one side, with four "A"s around "75" on the other, contains an enteric-coated core of diclofenac 75 mg, surrounded by an outer mantle containing misoprostol 200 µg. Nonmedicinal ingredients: castor oil, cellulose, colloidal silicon dioxide, cornstarch, crospovidone, hydroxypropyl methylcellulose, lactose, magnesium stearate, methacrylic acid copolymer, povidone, sodium hydroxide, talc, and triethyl citrate.

What should I NOT take with Arthrotec?

This medication should not be used by anyone who: currently has or recently had inflammatory diseases of the stomach and intestines such as stomach or intestinal ulcer or ulcerative colitis has significant liver impairment or liver disease has severely impaired or deteriorating kidney function is currently taking other NSAIDs is pregnant is or may be allergic to diclofenac, misoprostol, or any of the ingredients of the medication is or may be allergic to drugs similar to misoprostol (prostaglandins and their analogues) has had an allergic reaction to ASA or other anti-inflammatory medications

Are there any other precautions or warnings for Arthrotec?

Fluid and electrolyte balance: Fluid retention and edema have been reported with use of this medication. Diclofenac - misoprostol should be used with caution by anyone who: has certain heart conditions (e.g., congestive heart failure) has high blood pressure has kidney disease or reduced kidney function is recovering from a surgical operation under general anesthesia has any other condition that might lead to fluid retention There is a risk of high blood potassium with use of this medication. People most at risk are seniors, those having conditions such as diabetes or kidney failure, and those taking beta-adrenergic blockers, angiotensin converting enzyme (ACE) inhibitors, or some diuretics (water pills). Gastrointestinal: The presence of misoprostol in this medication may protect against the damaging effects of diclofenac on the inside lining of the stomach wall. However, serious problems such as stomach ulcers, perforation, and stomach bleeding, with or without symptoms, may still occur in patients treated with diclofenac. These complications can occur at any time, and are sometimes severe enough to require immediate medical attention. The risk of ulcers and bleeding are increased for people taking higher doses of this medication for longer periods of time. Minor stomach problems, such as heartburn, are common and usually develop early in therapy. Diclofenac - misoprostol should be taken under close medical supervision by those prone to irritation of the stomach and intestines, particularly those who have had a stomach ulcer, bloody stools, diverticulosis, or other inflammatory disease of the stomach or intestines (such as ulcerative colitis or Crohn's disease). In these cases, the doctor must weigh the benefits of treatment against the possible risks. Stop taking the medication and contact your doctor immediately if you experience symptoms or signs suggestive of stomach ulcers or bleeding in the stomach (black, tarry stools). These reactions can occur at any time during treatment without warning. Kidney function: Long-term use of diclofenac - misoprostol may lead to a higher risk of reduced kidney function. This is most common for people who already have kidney disease, liver disease, or heart failure; ipeople who take diuretics (water pills); and seniors. Occupational hazards: Headache, dizziness, lightheadedness, and confusion have been reported by some people who take this medication. Avoid operating motor vehicles and doing other potentially hazardous activities until you determine the effect this medication has on you. Pregnancy: Do not use this medication during pregnancy because it presents an increased risk of miscarriage. It is not recommended to become pregnant while taking diclofenac - misoprostol. If you suspect you are pregnant, stop using this medication. Breast-feeding: Nursing mothers should not use this medication because it may cause severe diarrhea for the infant. Children: Diclofenac - misoprostol is not recommended for children under 18 years of age. The safety, effectiveness, and dosages of the medication for this age group have not been established. Seniors: Seniors appear to have a higher risk of side effects and should use the lowest effective dosage under close medical supervision.