Premplus

Common Name: conjugated estrogens - medroxyprogesterone

How does Premplus work?

Estrogen and progesterone are female hormones that are produced by the ovaries. When used together they are often referred to as "hormone replacement therapy" or "HRT". During menopause, the ovaries produce less estrogen and progesterone and symptoms can occur. This medication is used for the management of menopausal symptoms such as abnormal uterine bleeding, hot flashes, sweating, and chills. Each package of medication contains 28 estrogen (conjugated estrogens) tablets and 28 progesterone (medroxyprogesterone) tablets. This combination of hormone replacement therapy may also help prevent osteoporosis caused by estrogen deficiency when combined with diet, calcium, and exercise. This medication is designed for use by women who have not had their uterus removed. The progesterone ingredient of the medication is present to reduce the risk of endometrial (uterine) cancer posed by estrogen and would not be required by women who have had a hysterectomy (i.e., they have had their uterus removed). Your doctor may have suggested this medication for conditions other than the ones listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. Do not stop taking this medication without consulting your doctor.

How should I use Premplus?

Each package of medication contains one 28-day treatment cycle. The starting dose is 1 maroon tablet (conjugated estrogen) plus 1 white tablet (medroxyprogesterone) taken once daily for 28 days. Once the package of tablets is finished, a fresh package is started the following day. Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are using the medication without consulting your doctor. It is very important that this medication be used on a regular schedule as prescribed by the doctor. If you miss a dose of this medication apply it as soon as you remember it. If it is almost time for your next dose, skip the missed dose and carry on with your regular schedule. Do not double-up on doses.

What form(s) does Premplus come in?

Tablets

What should I NOT take with Premplus?

This medication should not be used by anyone who: has liver dysfunction or disease has or has had known or suspected breast or endometrial (lining of the uterus) cancer has endometrial hyperplasia has undiagnosed abnormal vaginal bleeding has or has had blood clots in the heart has diseases of circulation or clotting (thrombophlebitis, thrombosis, or other thromboembolic disorders such as stroke) or has a history of these conditions associated with estrogen use is or may be pregnant is allergic to any ingredient of the medication

Are there any other precautions or warnings for Premplus?

Blood pressure: Increased or decreased blood pressure may occur for women using this medication. Blood pressure should be monitored with estrogen use. Blood problems: Women taking estrogen alone or in combination with progesterone have been reported to have an increased risk of conditions associated with blood clotting. Although the risk is small, it's important to be aware of this possibility during estrogen replacement therapy and to report any unusual symptoms to your doctor. Women with severe varicose veins or severe obesity, and those needing to stay in bed for three weeks or more, are generally considered to be at increased risk of blood clots. Breast cancer: Breast cancer is a disease with multiple causes and it increases in frequency with age. Much is unknown about the causes of breast cancer. Studies indicate an increased risk of breast cancer with long-term use of estrogen replacement therapy. There is a need for caution for women who have a strong family history of breast cancer, for those who develop breast nodules or fibrocystic disease of the breast, or for those who have abnormal mammograms. Other known risk factors in the development of breast cancer such as not having children, obesity, early onset of menstruation, late age at first full-term pregnancy, and late age at menopause should also be evaluated. Women taking estrogens should have regular breast examinations and should learn how to do breast self-examination. This medication must not be applied to the breasts, as it may have harmful effects on the breast tissue. Discuss the benefits and risks with your doctor so that you can make an informed choice about using this medication. Cholesterol: When taken by mouth, estrogen can increase triglycerides in the blood. Your doctor may check your cholesterol levels while you are taking estrogen. Diabetes: Estrogens may affect blood sugar control. Anyone with diabetes should carefully monitor their blood glucose levels while taking any medication containing estrogen. Endometrial cancer: There is evidence from several studies that estrogens, taken without progesterones, increase the risk of uterine cancer. Taking a progesterone (such as medroxyprogesterone) appropriately along with the estrogen reduces this risk to the same level as that of a woman who does not take estrogen. For this reason, all women who have not had their uterus removed should also take progesterone if they use estrogens. Fibroids: This medication may worsen fibroids, causing sudden enlargement, pain, or tenderness. If you notice these effects, contact your doctor. Fluid retention: Estrogen may cause fluid retention. Women with heart or kidney problems, epilepsy, or asthma should be monitored carefully when taking it. Gallbladder: An increased risk of gallbladder disease has been reported in postmenopausal women taking oral estrogens. Pregnancy: This medication should not be used during pregnancy. If you become pregnant while taking this medication, contact your doctor. Breast-feeding: Estrogen is not safe for use during breast-feeding. A decision should be made whether to discontinue nursing or to discontinue the medication, taking into account the importance of the medication to the mother. Children: The safety and effectiveness of this medication have not been established for use by children.