Crixivan

Common Name: indinavir

How does Crixivan work?

Indinavir is used in combination with other HIV drugs to treat the infection caused by the human immunodeficiency virus (HIV). HIV is the virus responsible for acquired immune deficiency syndrome (AIDS). Indinavir is one of a class of drugs called protease inhibitors. Protease is an enzyme that is needed by HIV to reproduce. Indinavir blocks the action of protease. This medication does not cure AIDS and does not prevent it from being spread to others. It does slow further growth or reproduction of HIV when used in combination with other drugs, and it seems to slow down the destruction of the immune system. This may help to delay the development of problems that are related to AIDS or HIV disease.

How should I use Crixivan?

The recommended dose of indinavir is 800 mg taken with water every eight hours, one hour before or two hours after a meal. It may also be taken with other liquids such as skim milk, juice, coffee, or tea or with a snack (e.g., dry toast with jelly, apple juice, or corn flakes with skim milk and sugar). Do not take indinavir with meals that are high in fat or calories, as this will reduce your body's ability to absorb the drug, which reduces its effectiveness. Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the one above, do not change the way that you are taking the medication without consulting your doctor. It is important to drink extra fluids while taking this medication so that more urine is passed and kidney stones are prevented. Discuss how much fluid you should drink with your doctor. Usually about 1.5 litres (48 ounces) of fluid per day is recommended. It is very important to take this medication on a regular basis as prescribed. The doses should be spaced as close to every eight hours as possible. If you miss a dose by more than 2 hours, do not take it later in the day. Simply continue to follow your usual schedule. Do not double up on doses. If you forget many doses in a row, talk to your doctor about how to resume dosing. With most antiretroviral drugs, a response can be seen within the first few days, but the maximum effect may take 12 to 16 weeks. Indinavir should be stored at room temperature in a tightly closed container and protected from moisture.

What form(s) does Crixivan come in?

Indinavir is supplied as 200 mg and 400 mg white semitranslucent capsules. Nonmedicinal ingredients include lactose, magnesium stearate, gelatin, silicon dioxide, sodium lauryl sulfate, and titanium dioxide. This medication does not contain starch, gluten or yeast.

What should I NOT take with Crixivan?

Indinavir should not be taken by anyone with significant sensitivity or allergy to any of the ingredients of the medication. Indinavir must not be taken at the same time as: cisapride triazolam midazolam terfenadine astemizole ergot derivatives (e.g., ergotamine, dihydroergotamine, methysergide)

Are there any other precautions or warnings for Crixivan?

Liver function: Some people with reduced liver function may require a lower dose of indinavir. Pregnancy: Adequate studies of this drug in pregnant women are not available. Indinavir should not be taken by pregnant women unless the potential benefits outweigh the risks. Talk to your doctor for guidance. Breast-feeding: Breast-feeding is not recommended for HIV-positive women. Children: The safety and effectiveness of indinavir have not been established for children. Seniors: The safety and effectiveness of indinavir have not been established for seniors.